Boeing - Usually known for their commercial airliner manufacturing, Boeing plays an integral part in national missile defense, from missile development, to space launch, to anti-satellite forces and even such high tech projects as the airborne laser.

Lockheed Martin - A major defense contractor, Lockheed Martin works hand in hand with the BMDO in developing effective missile defenses. The Martin Marietta Corporation, merged with Lockheed in 1995, was the prime contractor of the Brilliant Pebbles space based missile defense system developed during the 1990s. Until scrapped by President Clinton, Martin Marietta's design was well along in development and could have been operational today.

TRW - Thompson Ramo Wooldrige is involved in a wide range of missile defense activities specializing in the Space Based Laser, the Tactical High Energy Laser, the SBIRS low program, and battle management command and control systems.